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Indeed, the sales number of antidiabetics is increasing every year. Met is an oral biguanide insulinsensitizing drug recognized as the firstline treatment of patients with TDM. Pio is an insulin sensitizing TZD also commonly used to treat TDM.It is a potent synthetic activator of the PPAR, which heterodimerizes with retinoid X receptor.This heterodimer binds to nuclear responsive elements, modulating the transcription of genes that play a role in the metabolism of glucose and lipids. Interestingly, several effects not associated with the antihyperglycaemic functions have been reported to this drug, such as beneficial effects on lipid metabolism. As opposed to DM prevalence, the fertility rates have been decreasing in the recent years.Several authors suggest that these two events may be related for various reasons.For instance, there is a growing number of men developing DM during reproductive age, particularly adolescents and young adults. In fact, the vast majority of TDM cases are detected before the age of and there is an increasing number of children and adolescents with TDM. Nevertheless, the effects of DM in male reproductive health <a href="http://www.targetmol.com/compound/Talabostat-mesylate"></a> remain largely unknown.Although both are metabolic modulators and SC metabolism is essential for spermatogenesis, their isolated and combined effect in these cells metabolism remains scarcely known.As discussed, DM is a chronic disease and a leading cause for morbidity and mortality.There is an increasing   number of children, adolescents and young adults with DM subjected to a long term use of antidiabetics.Glucose is essential for male reproductive function.Several reports discussed the impact of DM in male fertility and suggested that deregulated glucose metabolism is a key factor. Diabetic men face fertility problems with different degrees of severity depending of several factors.The sale of antidiabetics is rapidly increasing and their safety to male reproductive health remains unknown.Pio is a synthetic insulinsensitizing drug which acts as an agonist of PPAR, though PPAR independentmediated effects are also reported. However, possible adverse side effects have been highlighted and remain under debate. Pio effects in male reproductive system remain unknown though it was recently reported that it improves erectile function of rats with bilateral cavernosal nerve injury. We have previously shown that GLUT protein levels are sensitive to these cells energetic needs. Thus, stimulation of glycolytic flux may induce a decrease in protein levels of this transporter to avoid an uncontrolled uptake of glucose, which would be deleterious for the cell.Glucose enters the cell and usually follows the glycolytic pathway.The emerging number of men in reproductive age with DM, together with an increasing incidence in children, adolescents and young adults highlight the need for studies assessing the safety of antidiabetic drugs on pivotal functions for male reproductive health.These novel findings suggest a possible protective role for this antidiabetic on male reproductive function.Along with this increase, DM prevalence has also increased dramatically.One of the reasons for these increases is the alarming upraising of the number of men developing DM in reproductive age.The vast majority of patients with TDM will progressively need more complex therapeutic procedures to control hyperglycemia.Thus, it urges the study of the possible mechanisms of these antidiabetics to male fertility as they can have beneficial or deleterious effects that can lead to subfertility or infertility.

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