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The protective effect of the hydroethanolic extract of artichoke against altered biochemical parameters in rats fed with leadcontaining diet was evaluated.These results clearly show that the artichoke extract in leadpoisoned rats has suitable chelating properties for the reduction of blood lead levels. The results was confirmed application of artichoke extracts as endothelium protecting <a href="http://www.targetmol.com/compound/Megestrol-acetate"></a> agents. The influence of supplementation with artichokeleaf extract on parameters describing balance between oxidants and antioxidants in competitive rowers was investigated and it was demonstrated that consuming artichokeleaf extract, a natural vegetable preparation of high antioxidant potential, resulted in higher plasma TAC than placebo but did not limit oxidative damage to erythrocytes in competitive rowers subjected to strenuous training. The hepatoprotective properties of polyphenolic extracts from the edible part of artichoke was evaluated and it was illustrated that AE reduced cell viability and had an apoptotic activity on a human liver cancer cell   line. The effect of the artichoke extract on oxidation of palmiticC acid administered intravenously to rats at a dose and mgkg bwwas investigated.The results demonstrate that the AE possess stimulatory properties with respect to oxidation of palmitic acid administered to rats, and provide new information on the mechanism of antilipemic activity of the extract associated with activation of lipid oxidation in the organism. The potential capacity to selectively stimulate the growth of intestinal bacteria associated with health shown by fraction A can be ascribed to its high inulin and low methylation degree pectin contents. The more interesting fractions for use as functional ingredients were those situated closer to the artichoke heart and thermally treated. The results reveals significant new data on the interaction of inoculated fungi with artichoke plant as ecological roles that can be exploited for the protection of plants. It found that in the supplemented group, the homeostasis model assessment, the body mass index and the susceptibilitytohunger score of the TFEQ, decreased significantly after intervention; these parameters did not change in the controls.This treatment appears potentially useful in the management of overweight and dysglycaemia. The results obtained constitute the first evidence of a hypoglycemic effect of an artichoke preparation in laboratory rodents and confirm previous observations made in humans. The genotoxic results showed that leaf extracts did not increase micronuclei in peripheral blood cells.Compared to the control group, a significant increase in comet assay values was observed only in bone marrow of group treated with mgkg, the highest dose tested, indicating that artichoke tea should be consumed with moderation. Artichoke leaf extract can cause increase in urinary excretion of nicotine in longer post administration times.It was observed that coadministration of nanozeolites and the leaf extract has the synergetic effect on increasing the urinary excretion of nicotine. Theresults were also confirmed that daily consumption of VLCI extracted from globe artichoke exerted a pronounced prebiotic effect on the human faecalmicrobiota composition and was well tolerated by all volunteers. Thereby, eating stored artichoke leads to consumption of an inulin quantity that does not provoke unwanted symptoms related to gas production but sufficient to have a prebiotic effect.

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